Several editions of Panama Souvenir Playing Cards were issued by the USPCC between 1908 - 1926. The design of the cards varied between editions, and different 'fact' and map cards were also included.

Early editions of Panama Souvenir Playing Cards depict views of the canal being dug out and built by labourers from different countries. Later editions show U.S. Navy warships passing through the canal, like the USS Maryland, USS Colorado, USS Pensylvania, USS California, etc.